Histone H3K4me3 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHistone H3K4me3
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Chromatin Immunoprecipitation (CHIP)
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DescriptionModulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin (1). The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination (2-5). These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression (6). In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 (4, 7). Histone H3 is primarily acetylated at Lys9, 14, 18,
ImmunogenImmunogen: A synthetic methylated peptide corresponding to residues surrounding K4 of human histone H3 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Names[HIST1H3J; H3/j; H3FJ; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/I; HistoneH3/j; Histone H3/k; Histone H3/l; HIST3H3]
Gene, Accession #Gene ID: 8290, NCBI: NP_003484.1, UniProt: Q16695
Catalog #MBS8527387
Price$310
Order / More InfoHistone H3K4me3 Antibody from MYBIOSOURCE INC.
Product Specific References1. Workman, J.L. and Kingston, R.E. (1998) Annu Rev Biochem 67, 545-79. 2. Hansen, J.C. et al. (1998) Biochemistry 37, 17637-41. 3. Strahl, B.D. and Allis, C.D. (2000) Nature 403, 41-5. 4. Cheung, P. et al. (2000) Cell 103, 263-71. 5. Bernstein, B.E. and Schreiber, S.L. (2002) Chem Biol 9, 1167-73. 6. Jaskelioff, M. and Peterson, C.L. (2003) Nat Cell Biol 5, 395-9. 7. Thorne, A.W. et al. (1990) Eur J Biochem 193, 701-13. 8. Hendzel, M.J. et al. (1997) Chromosoma 106, 348-60. 9. Goto, H. et al. (1999) J Biol Chem 274, 25543-9. 10. Preuss, U. et al. (2003) Nucleic Acids Res 31, 878-85. 11. Dai, J. et al. (2005) Genes Dev 19, 472-88.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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