TrkA Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | TrkA |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to TrkA. The family of Trk receptor tyrosine kinases consists of TrkA, TrkB and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. TrkA regulates proliferation and is important for development and maturation of the nervous system (1). Phosphorylation at Tyr490 is required for Shc association and activation of the Ras-MAP kinase cascade. Residues Tyr674/675 lie within the catalytic domain, and phosphorylation at this site reflects TrkA kinase activity (2-6). Point mutations, deletions and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA. Many malignan |
| Immunogen | Immunogen: A synthetic -peptide of human TrkA |
| Other Names | [NTRK1; NTRK1 DKFZp781I14186 MTC TRK TRK1 TRKA Trk-A p140-TrkA High affinity nerve growth factor receptor Neurotrophic tyrosine kinase receptor type 1 TRK1-transforming tyrosine kinase protein p140-TrkA], [NTRK1; NTRK1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; MTC; TRK; TRKA; Trk-A] |
| Gene, Accession # | Gene ID: 4914, NCBI: NP_001007793.1, UniProt: P04629 |
| Catalog # | MBS125190 |
| Price | $275, $430, $655 |
| Order / More Info | TrkA Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Pierotti, M.A. and Greco, A. (2006) Cancer Lett 232, 90-8. 2. Segal, R.A. and Greenberg, M.E. (1996) Annu Rev Neurosci 19, 463-89. 3. Stephens, R.M. et al. (1994) Neuron 12, 691-705. 4. Obermeier, A. et al. (1993) EMBO J 12, 933-41. 5. Obermeier, A. et al. (1994) EMBO J 13, 1585-90. 6. Yao, R. and Cooper, G.M. (1995) Science 267, 2003-6. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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