Synaptopodin Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Synaptopodin |
| Clone | [G1D4] |
| Host Species | Mouse |
| Reactive Species | n/a |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 5 mL |
| Concentration | n/a |
| Applications | Immunofluorescence Assay, Immunohistochemistry - Formalin/Paraffin, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes differentiated podocytes (glomerular visceral epithelial cells) in vivo and in vitro (weaker additional reaction with arterial endothelial cells), co-localization with alpha-actinin. Does not react with parietal cells. Reacts with a subset of exclusively telencephalic synapses. Differentiation-dependent expression during postnatal maturation of rat brain. Differentiation-dependent expression in cultured hippocampal neurons. Reacts specifically with synaptopodin, a prolin-rich actin-binding protein with 2 binding sites for actin. Cross-reacts with human, bovine, rat, mouse, guinea pig and gerbil. Does not cross-react with rabbit, frog or chicken. |
| Immunogen | Immunogen: Isolated rat kidney glomeruli. Affinity Constant: Not determined |
| Other Names | n/a |
| Gene, Accession # | NCBI: AAQ07403.1 |
| Catalog # | MBS312195 |
| Price | $690 |
| Order / More Info | Synaptopodin Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Mundel, P., et al., (1991), Podocytes in Glomerulus of Rat Kidney Express a Characteristic 44 kD Protein, J. Histochem. and Cytochem., Vol. 39, No. 8, 1047-1056.2.Mundel, P., et al., (1995), Structure and function of podocytes: an update, Anat. Embryol., 192, 385-397.3. Mundel, P., et al., (1997), Phenotypic conversion and differention of human and rat podocytes in vitro, J. Am. Soc. Nephrol., 8, 89708-89705.4. Mundel, P., et al., (1997), Synaptopodin, an actin-associated protein in telencephalic dendrites and in renal podocytes, J. Cell Biol., Vol 139(1), 193-204.5. Mundel, P., et al., (1997), Rearrangements of cytoskeleton and cell contacts induce process formation and postmitotic differentiation of conditionally immortalized mouse podocyte cell lines, Exp. Cell Res., 236, 248-258.6. Kobayashi, N., et al., (1998), Non-uniform microtubular polarity, established by CHO1/MKLP1 motor protein, is necessary for process formation of podocytes, J. Cell Biol., 143, 1961-1970.7. Barisoni, L., et al., (1999), The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy, J. Am. Soc. Nephrol., 10, 51-61.8. Kihara, I., et al., Origin of hyperplastic epithelial cells in idiopathic collapsing glomerulopathy, Histopathology, 67(6), 537-547.9. Asanuma, K., et al., (2005), Synaptopodin regulates the actin-binding activity of alpha-actinin in an isoform-specific manner, J. Clin. Invest., 115, 1188-1198 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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