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Antigenic Specificity | MEFV |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been show |
Immunogen | Immunogen: Recombinant Human Pyrin protein (268-374AA) |
Other Names | [Pyrin; Marenostrin; MEFV; MEF; TRIM201 Publication] |
Gene, Accession # | [MEFV], Gene ID: 4210, NCBI: NP_000234.1, UniProt: O15553 |
Catalog # | MBS7109899 |
Price | $160, $235 |
Order / More Info | MEFV Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |