Beta-secretase 1 (CT) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Beta-secretase 1 (CT) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Accumulation of the amyloid- (A) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer?s disease. A peptide is generated by proteolytic cleavage of the amyloid protein precursor (APP) at - and -sites by two proteases. APP is first cleaved by secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for secretase to generate the 4 kDa amyloid- peptide, which is deposited in the brains of all suffers of Alzheimer?s disease. The long-sought secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2)1-4. BACE/Asp2 is a nove |
| Immunogen | Immunogen: Synthetic peptide corresponding to amino acids 485 to 501 of human BACE. Sequence differs from that of rat and mouse by one amino acid. |
| Other Names | [BACE; KIAA1149; Beta-site amyloid precursor protein cleaving enzyme 1], [BACE1; BACE1; ASP2; BACE; HSPC104; BACE; KIAA1149; ASP2; Asp 2] |
| Gene, Accession # | Gene ID: 23621, NCBI: NP_001193978.1, UniProt: P56817 |
| Catalog # | MBS395443 |
| Price | $510 |
| Order / More Info | Beta-secretase 1 (CT) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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