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Antigenic Specificity | CD25 |
Clone | PC61 |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG1 lambda |
Format | allophycocyanin (APC) conjugate |
Size | 100 µg |
Concentration | 0.2 mg/mL |
Applications | Flow Cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Allophycocyanin conjugated CD25 Monoclonal Antibody was Protein G Purified from tissue culture supernatant and is directed against mouse CD25. Reactivity is observed against mouse CD25. Cross reactivity with CD25 from other sources has not been tested. CD25 is a 55KDa transmembrane glycoprotein consisting of a heavily glycosylated extracellular domain, a transmembrane region and a short cytoplasmic tail. It is expressed during early stages of thymocytes development and in activated CD4+ memory T-lymphocytes. CD25 heterodimerizes with IL2R-beta and IL-2R gamma and forms the tripartite high affinity IL-2 receptor complex. It increases the specificity and affinity of IL-2 receptor complex for IL-2 ligand and is necessary for receptor clustering required for augmentation of IL-2 signaling. Mutations in CD25 result in severe immunodeficiency. |
Immunogen | Anti-CD25 Antibody (Monoclonal) was produced by repeated immunizations with IL-2-dependent cytolytic mouse T-cell clone B6.1. |
Other Names | Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, p55, CD25 Antibody |
Gene, Accession # | Il2r, Gene ID: 16184, NCBI: NP_032393.3, UniProt: P01590 |
Catalog # | 200-526-M73 |
Price | $495 |
Order / More Info | CD25 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |