GABA(A) Receptor alpha 2 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | GABA(A) Receptor alpha 2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-GABA(A) Receptor alpha 2 antibody is directed against rat GABA(A) receptor alpha 2 protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Labeling is absent in α2-subunit knockout animals. Reactivity is expected from bovine, canine, human, non-human primate, Zebrafish. Cross reactivity to GABA(A) from other species has not been determined. GABA(A) Receptor alpha 2 Antibody detects GABA(A) receptor alpha 2 protein. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. GABA(A) receptor alpha 2 antibody is ideal for investigators involved in Neuroscience. |
| Immunogen | Anti-GABA(A) Receptor alpha 2 Antibody was produced in rabbit by repeated immunizations with a fusion protein from the cytoplasmic loop of the rat receptor alpha 2 subunit. |
| Other Names | Gamma-aminobutyric acid receptor subunit alpha-2, GABA(A) receptor subunit alpha-2 |
| Gene, Accession # | Gabra2, Gene ID: 61856, NCBI: NP_001129251.1, UniProt: P23576 |
| Catalog # | 600-401-D45 |
| Price | $475 |
| Order / More Info | GABA(A) Receptor alpha 2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 34546336 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
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