CD25 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | CD25 |
| Clone | PC61 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG1 lambda |
| Format | phycoerythrin (RPE) conjugate |
| Size | 100 µg |
| Concentration | 0.2 mg/mL |
| Applications | Flow Cytometry, IF Microscopy |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Phycoerythrin conjugated CD25 Monoclonal Antibody was Protein G Purified and is directed against mouse CD25. Reactivity is observed against mouse CD25. Cross reactivity with CD25 from other sources has not been tested. The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells. The PC61.5 antibody is used as a marker for T cells, B cells and dendritic cell subsets. Expression of CD25, CD4 and the transcription factor Foxp3 is regarded as a phenotypic signature for Treg cells. As such, this antibody is widely used for depletion of Treg cells in vivo, as well as to distinguish Treg cells from naive or conventional T cells which are CD25. |
| Immunogen | Anti-CD25 Antibody (Monoclonal) was produced by repeated immunizations with IL-2-dependent cytolytic mouse T-cell clone B6.1. |
| Other Names | Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, p55, CD25 Antibody |
| Gene, Accession # | Il2r, Gene ID: 16184, NCBI: NP_032393.3, UniProt: P01590 |
| Catalog # | 200-508-M73 |
| Price | $365 |
| Order / More Info | CD25 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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