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Antigenic Specificity | CD25 |
Clone | BC96 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 kappa |
Format | allophycocyanin (APC) conjugate |
Size | 500 µL |
Concentration | 0.025 mg/mL |
Applications | Flow Cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Allophycocyanin conjugated CD25 Monoclonal Antibody was purified from tissue culture supernatant via affinity chromatography and is directed against human CD25. Reactivity is observed against human CD25, Baboon, Chimpanzee, Cynomolgus, and Rhesus. Cross reactivity with CD25 from other sources has not been tested. Anti-CD25 is conjugated with APC under optimal conditions and the solution is free of unconjugated APC. The BC96 antibody is specific for human CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Signaling via CD25 may modulate Th17 and Treg cell differentiation, and has been shown to play a role in the function of dendritic cells. The BC96 antibody may be used as a marker for expression of CD25 during T and B cell development, on activated mature T and B cells, and for its expression at high levels on natural T regulatory cells (nTreg cells) in the thymus or periphery, and on induced peripheral Tregs. |
Immunogen | Anti-CD25 Antibody (Monoclonal) was produced by repeated immunizations with CD25 antigen. |
Other Names | Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, p55 |
Gene, Accession # | IL2RA, Gene ID: 3559, NCBI: NP_000408.1, UniProt: P01589 |
Catalog # | 200-326-N25 |
Price | $399 |
Order / More Info | CD25 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |