ROBO-1, C-Terminus Antibody from ROCKLAND IMMUNOCHEMICALS INC.

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Antigenic SpecificityROBO-1, C-Terminus
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat, dog
Isotypen/a
Formatimmunoaffinity purified
Size100 µg
Concentration1.0 mg/mL
ApplicationsELISA,Immunohistochemistry,IF Microscopy,Immunoprecipitation,Western Blot,
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DescriptionAnti-ROBO-1 (RABBIT) Antibody - 600-401-692. This affinity purified antibody is directed against human ROBO-1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with this protein from human, mouse, rat and dog sources based on 100% homology for the immunogen sequence. Cross reactivity will occur with all isoforms of ROBO-1. Cross reactivity with ROBO-1 homologues from other sources has not been determined. ROBO-1 (also called Roundabout homolog 1 precursor and Deleted in U twenty twenty (DUTT)) functions as a receptor for SLIT1 and SLIT2. The SLIT proteins are thought to act as a molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. ROBO-1 may also be required for lung development. ROBO-1 is a type I membrane protein. ROBO-1 is a widely expressed protein with the exception of the kidney. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO-1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line. Multiple splice variants have been identified for this protein.
ImmunogenThis affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an C-Terminal region near amino acids 1625-1650 of Human ROBO-1.
Other Namesrabbit anti-ROBO1 antibody, ROBO 1, ROBO-1, hROBO-1, Roundabout homolog 1, Deleted in U twenty twenty, DUTT1, DUTT-1
Gene, Accession #ROBO1, Gene ID: 6091, UniProt: Q2M1J3, NCBI: AAI12337.1
Catalog #600-401-692
Price$369
Order / More InfoROBO-1, C-Terminus Antibody from ROCKLAND IMMUNOCHEMICALS INC.
Product Specific Referencesn/a
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654

orders@rockland-inc.com
Technical Support: tech@rockland-inc.com

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