Alpha Synuclein Antibody from STRESSMARQ BIOSCIENCES INC.

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Antigenic SpecificityAlpha Synuclein
Clone3C11
Host SpeciesMouse
Reactive Specieshuman, mouse, rat
IsotypeIgG1
FormatATTO 390 conjugate
Size100 µg
Concentration1 mg/ml
ApplicationsWB | DB | ICC/IF | ELISA
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DescriptionMouse Anti-Human Alpha Synuclein Monoclonal IgG1. Binds within the 81-130 aa region of human alpha synuclein, determined using WB and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Alpha synuclein. Band at ~30 kDa is a dimer. A 1:1000 dilution of SMC-530 was sufficient for detection of Alpha Synuclein in 15 µg of human brain cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
ImmunogenHuman alpha synuclein monomer
Other NamesAlpha Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, PARK1, PARK 1, alphaSYN, PARK 4, PARK4, Parkinson disease familial 1, Parkinson disease (autosomal dominant, Lewy body) 4, SYN
Gene, Accession #Gene ID: 6622, Accession: NP_000336.1, SwissProt: P37840
Catalog #SMC-530D-A390
Price$342 US
Order / More InfoAlpha Synuclein Antibody from STRESSMARQ BIOSCIENCES INC.
Product Specific References1. ``Genetics Home Reference: SNCA''. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.
STRESSMARQ BIOSCIENCES INC.
STRESSMARQ BIOSCIENCES INC.
STRESSMARQ BIOSCIENCES INC.
PO Box 55036
Cadboro Bay
Victoria BC V8N4G0 CANADA
P: +1-250-294-9065
F: +1-250-294-9025

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