Alpha Synuclein Antibody from STRESSMARQ BIOSCIENCES INC.

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Antigenic SpecificityAlpha Synuclein
Host SpeciesMouse
Reactive Specieshuman, mouse, rat
FormatATTO 565 conjugate
Size100 µg
Concentration1 mg/ml
ApplicationsWB | DB | ICC/IF | ELISA
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DescriptionMouse Anti-Mouse Alpha Synuclein Monoclonal IgG1. Binds within the 101-130 aa region of human alpha synuclein, determined using Dot blot and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Alpha synuclein. Band at ~40 kDa is a trimer. A 1:1000 dilution of SMC-531 was sufficient for detection of Alpha Synuclein in 15 µg of human brain cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
ImmunogenMouse alpha synuclein aggregate
Other NamesAlpha Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, PARK1, PARK 1, alphaSYN, PARK 4, PARK4, Parkinson disease familial 1, Parkinson disease (autosomal dominant, Lewy body) 4, SYN
Gene, Accession #Gene ID: 20617, Accession: NP_001035916.1, SwissProt: O55042
Catalog #SMC-531D-A565
Price$341 US
Order / More InfoAlpha Synuclein Antibody from STRESSMARQ BIOSCIENCES INC.
Product Specific References1. ``Genetics Home Reference: SNCA''. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.
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