Histone H3 Antibody from STRESSMARQ BIOSCIENCES INC.

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Antigenic SpecificityHistone H3
Clone2E11
Host SpeciesMouse
Reactive Specieshuman, mouse, rat
IsotypeIgG1
FormatATTO 488 conjugate
Size100 µl
Concentrationn/a
ApplicationsWB
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DescriptionMouse Anti-Human Histone H3 (tri Methyl Lys4) Monoclonal IgG1. Detects endogenous Histone H3 (tri methyl K4) protein. A 1:1000 dilution of SMC-252 was sufficient for detection of Histone H3 in 10 µg of Human, Rat, Mouse HeLa, Testis Tissue, Raw 264.7 cell lysates by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody. Histone H3 is a 17 kD nuclear protein that is a component of an octamer containing pairs of each of four core histones (H2A, H2B, H3, H4). The core histones create nucleosome structure of chromosomal fiber in eukaryotes and are dynamic in gene regulation. The histones exhibit cell cycle-dependent transcriptional regulation except for the variant H3.3 which is cell cycle-independent. Histone H3 can be modified by phosphorylation, acetylation, ubiquitination, ribosylation, and methylation. Histone H3 has been shown to interact with Rsk-2, MSK1, GCN5 family of HATs, HDACs, PARP, SET7/9, and CARM1. Histones play a cental role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
ImmunogenPrepared by immunizing synthetic peptide coupled to KLH.
Other NamesH3 histone family, member A, H3/A, H31_HUMAN, H3FA, Hist1h3a, histone 1 H3a, Histone cluster 1 H3a, Histone H3.1
Gene, Accession #SwissProt: P68431/Q71DI3/P84243
Catalog #SMC-252D-A488
Price$302 US
Order / More InfoHistone H3 Antibody from STRESSMARQ BIOSCIENCES INC.
Product Specific References1. Wu R., et al. (1981) Cell. 27:321. 2. Strahl B., et al. (2000) Nature. 403:41. 3. Bauer U., et al. (2002) EMBO Rep. 3:39. 4. Frank D., et al. (2003) Gene. 312:135.
STRESSMARQ BIOSCIENCES INC.
STRESSMARQ BIOSCIENCES INC.
STRESSMARQ BIOSCIENCES INC.
PO Box 55036
Cadboro Bay
Victoria BC V8N4G0 CANADA
P: +1-250-294-9065
F: +1-250-294-9025

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