PSD95 Antibody from STRESSMARQ BIOSCIENCES INC.

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Antigenic SpecificityPSD95
Clone7E3
Host SpeciesMouse
Reactive Specieshuman, mouse, rat, bovine
IsotypeIgG1
FormatATTO 488 conjugate
Size100 µg
Concentration1 mg/ml
ApplicationsWB | IHC | ICC/IF | AM
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DescriptionMouse Anti-Rat PSD95 Monoclonal IgG1. Detects ~100kDa. An additional protein of >100kDa is also detected. Additional cross-reactive bands are detected at ~75kDa and 50kDa in rat and mouse samples. 1 µg/ml was sufficient for detection of PSD-95 on 20 µg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse IgG: HRP as the secondary. Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3, 4).PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD95 are associated with autism (7).
ImmunogenRecombinant rat PSD-95
Other NamesPSD 95, PSD-95, DLG4, SAP90, Synapse-associated protein 90, Postsynaptic density protein 95, Disks large homolog 4
Gene, Accession #Gene ID: 29495, Accession: NP_062567.1, SwissProt: P31016
Catalog #SMC-123D-A488
Price$320 US
Order / More InfoPSD95 Antibody from STRESSMARQ BIOSCIENCES INC.
Product Specific References1. Chetkovich D.M., Bunn R.C., Kuo S.H., Kawasaki Y., Kohwi M., and Bredt D.S. (2002) J Neurosci. 22(15): 6415-25. 2. Cao J., Viholainen J.I., Dart C., Warwick H.K., Levland M.L. and Courtney M.J. (2005) J Cell Biol. 168(1): 117-26. 3. Kennedy M. (1997) Trends in Neurosci. 6: 264-268. 4. Irie M. et al. (1997) Science 277(5331): 1511-5. 5. Cai C. et al. (2006) J Biol Chem. 281: 4267-73. 6. Yao W.D. et al. (2004) Neuron 41: 625-38. 7. Cline H. (2005) Curr Biol. 15: R203-5.
STRESSMARQ BIOSCIENCES INC.
STRESSMARQ BIOSCIENCES INC.
STRESSMARQ BIOSCIENCES INC.
PO Box 55036
Cadboro Bay
Victoria BC V8N4G0 CANADA
P: +1-250-294-9065
F: +1-250-294-9025

info@stressmarq.com

http://www.stressmarq.com

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