A-803467 from ALOMONE LABS

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Product NameA-803467
DescriptionPurity: >99%. A-803467. A Potent and Selective Inhibitor of the TTX-Resistant Na\v\1.8 Channel.The TTX-resistant, Na\v\1.8 channel is expressed almost exclusively in the PNS and has been shown to mediate most of the well documented TTX-resistant currents of DRG neurons' action potentials. Hyperexcitability, manifested by increased action potential firing and coded information transfer to the CNS of nociceptive DRG neurons, probably lie on the basis of several pathological pain states. Both genetic and pharmacological evidence suggest that Na\v\1.8 channel might serve as a target in pain control.A-803467 is a potent and selective blocker of the TTX-resistant Na\v\1.8 channels. A-803467 is a state dependent inhibitor of the channel, with IC\50\ = 8 nM at depolarized membrane potential (-40 mV) and 80 nM at -100 mV. As an efficient inhibitor of TTX-resistant currents in DRG neurons, A-803467 was also effective as an analgesic in several rodent models of different pathological pain states. A-803467, was used as a pharmacological tool to demonstrate the expression of Na\v\1.8 in the heart conduction system and its contribution to QRS interval in the mouse heart.Ion Channel Modulators; Voltage - Gated Na+ Channel Blockers.
Size5 mg
Concentrationn/a
Applicationsn/a
Other Namesn/a
Gene, Accession, CAS #n/a
Catalog #A-105
Price$27.00
Order / More InfoA-803467 from ALOMONE LABS
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ALOMONE LABS
ALOMONE LABS
ALOMONE LABS
Jerusalem BioPark (JBP), Hadassah Ein Kerem
PO Box 4287
Jerusalem, 9104201 ISRAEL
P: +972-2-587-2202
F: +972-2-587-1101

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