Recombinant SARS-CoV-2 S Protein S1+S2 (R683A, R685A) (CF) from BIOLEGEND

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Product NameRecombinant SARS-CoV-2 S Protein S1+S2 (R683A, R685A) (CF)

SARS-CoV-2 is a respiratory virus which causes coronavirus disease 2019 (COVID-19). The coronavirus spike (S) glycoprotein is a class I viral fusion protein on the outer envelope of the virion that plays a critical role in viral infection by recognizing host cell receptors and mediating fusion of the viral and cellular membranes. The S glycoprotein is synthesized as a precursor protein consisting of about 1,300 amino acids that is then cleaved into an amino (N)-terminal S1 subunit (about 700 amino acids) and a carboxyl (C)-terminal S2 subunit (about 600 amino acids). Three S1/S2 heterodimers assemble to form a trimer spike protruding from the viral envelope. The S1 subunit contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells. Triggered by receptor binding, proteolytic processing and/or acidic pH in the cellular compartments, the class I viral fusion protein undergoes a transition from a metastable pre-fusion state to a stable post-fusion state during infection, in which the receptor-binding subunit is cleaved, and the fusion subunit undergoes large-scale conformational rearrangements to expose the hydrophobic fusion peptide, induce the formation of a six-helix bundle, and bring the viral and cellular membranes close for fusion. The trimeric SARS coronavirus (SARS-CoV-2) S glycoprotein consisting of three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 (ACE2) and mediates fusion of the viral and cellular membranes through a pre- to post-fusion conformation transition.  This SARS-CoV-2 S Protein S1+S2 is made with arginine-to-alanine substitution at positions 683 and 685 to help with stability of the protein against endogenous furin cleavage.

Size100 µg
Other NamesS1S2, S protein, Spike protein
Gene, Accession, CAS #n/a
Catalog #794206
Order / More InfoRecombinant SARS-CoV-2 S Protein S1+S2 (R683A, R685A) (CF) from BIOLEGEND
Product Specific ReferencesPubMed: 32986722
8999 BioLegend Way
San Diego CA 92121
P: (858) 455-9588
P: 1-877-Bio-Legend (246-5343)
F: (858) 455-9587

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