Human CellExp™ Coronavirus Spike Protein (MERS-CoV S1; 18-725), Recombinant from BIOVISION, INC.

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Product NameHuman CellExp™ Coronavirus Spike Protein (MERS-CoV S1; 18-725), Recombinant
DescriptionPurity >85%. MW: 25 kDa (Fc-tag). MERS-CoV spike protein plays an important role in virus binding and entry, and the development of MERS-CoV entry/fusion inhibitors targeting the S1 subunit, particularly the receptor-binding domain, and the S2 subunit, especially the HR1 region, of the MERS-CoV spike protein. Spike glycoprotein cleaved into three chains: S1, S2' and S2. S1 attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. S2' acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis. S2 mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Size10µg
Concentrationn/a
Applicationsn/a
Other NamesSpike glycoprotein, S glycoprotein, E2, Peplomer protein
Gene, Accession, CAS #S
Catalog #P1513-10
Price$175
Order / More InfoHuman CellExp™ Coronavirus Spike Protein (MERS-CoV S1; 18-725), Recombinant from BIOVISION, INC.
Product Specific Referencesn/a
BIOVISION, INC.
BIOVISION, INC.
BIOVISION, INC.
155 S. Milpitas Boulevard
Milpitas CA 95035
P: 408-493-1800
P: 800-891-9699
F: 408-493-1801

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