Neprilysin Inhibitor Screening Kit (Fluorometric) from BIOVISION, INC.

Search, find, compare suppliers for Neprilysin Inhibitor Screening Kit (Fluorometric) products.

Edit 
Product NameNeprilysin Inhibitor Screening Kit (Fluorometric)
DescriptionNeprilysin (NEP, EC 3.4.24.11), also known as neutral endopeptidase, enkephalinase, CD10, and common acute lymphoblastic leukemia antigen, is a type II zinc-containing transmembrane metalloproteinase. It is able to hydrolyze very important endogenous peptides, such as natriuretic atrial factor, enkephalins, substance P, bradykinin and amyloid beta-peptide. Thus, NEP is a potentially therapeutic target in important pathological conditions such as cardiovascular disease, prostate cancer, Alzheimer's disease and analgesia. NEP has also been used as a biological marker of a type of childhood leukemia called CALLA. NEP is currently a focus of interest in cardiovascular and neurobiological research. NEP inhibitors have shown promising results as potential treatment alternative for some conditions including hypertension, heart failure, renal failure, and improvement of β-cell function in obese type 2 diabetes mellitus. The combination of NEP inhibitor and angiotensin II type 1 receptor blockade has been used clinically to treat patients with chronic heart failure. BioVision's NEP Inhibitor Screening Kit can be used to screen for potential inhibitors of NEP activity. It utilizes the ability of an active NEP to cleave a synthetic MCA based peptide substrate to release a free fluorophore. The released MCA can be easily quantified using a fluorescence microplate reader. In the presence of an NEP specific inhibitor, the enzyme loses its activity which results in decrease of fluorescence intensity. The assay kit is simple and can be used to identify and characterize NEP inhibitors in a high-throughput format
Size100 assays
Concentrationn/a
ApplicationsScreening/characterizing/studying Neprilysin inhibitors/activators
Other Namesn/a
Gene, Accession, CAS #n/a
Catalog #K996-100
Price$525
Order / More InfoNeprilysin Inhibitor Screening Kit (Fluorometric) from BIOVISION, INC.
Product Specific Referencesn/a
BIOVISION, INC.
BIOVISION, INC.
BIOVISION, INC.
155 S. Milpitas Boulevard
Milpitas CA 95035
P: 408-493-1800
P: 800-891-9699
F: 408-493-1801

support@biovision.com

http://www.biovision.com

Facebook
Twitter
LinkedIn


Profile of BIOVISION, INC.
Return to Products

© 1980 - 2020 Linscott's Directory, Linscott's USA. All rights reserved.