Flumatinib from CAYMAN CHEMICAL COMPANY
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| Product Name | Flumatinib |
| Description | A Bcr-Abl inhibitor (IC50 = 1.2 nM); selective for Bcr-Abl over VEGFR2, c-Src, EGFR, and HER2 at 1 µM but does inhibit PDGFRβ and c-Kit (IC50s = 307.6 and 665.5 nM, respectively); inhibits the proliferation of K562 cells expressing wild-type Bcr-Abl (IC50 = 5.1 nM) and 32D cells expressing the Bcr-Abl mutations Bcr-AblQ252H, Bcr-AblY253F, Bcr-AblE255K, Bcr-AblM351T, and Bcr-AblH396P (IC50s = 76.3, 40.4, 123.2, 20.2, and 34.6 nM, respectively), which are resistant to imatinib; induces tumor regression and increases survival time in a K562 mouse xenograft model at 75 mg/kg per day; increases the viability of SARS-CoV-2-infected Vero E6 cells (EC50 = 1.6 µM) |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | HH-GV-678 |
| Gene, Accession, CAS # | CAS: 895519-90-1 |
| Catalog # | 36226-10 |
| Price | $62.00 |
| Order / More Info | Flumatinib from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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