A-443654 from CAYMAN CHEMICAL COMPANY

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Product NameA-443654
DescriptionA pan Akt inhibitor (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation; slows the progression of Akt-dependent tumors in vivo; concomitantly increases Akt Thr308 and Ser473 phosphorylation via a rapid feedback reaction
Size5 mg
Concentrationn/a
Applicationsn/a
Other NamesAkt1 Akt2 Akt3 proteins kinases B PKB cancers cells proliferation inhibitors biochemicals signals tranductions inhibits inhibitions Akt-1 Akt-2 Akt-3 Akts 1 2 3 PK A443654 A 443654 pan isoforms PKBα PKBβ PKBγ α β γ modulates metabolism survivals angiogenesis mitotic progressions bipolar spindles formations induces G2/M G2 M accumulations defects centrosomes separations monopolar arrays disorganized Akt-dependent dependent tumors in vivo mouses models phosphorylation Thr Thr308 308 Ser Ser473 473 humans lines mechanisms rapid feedback reactions
Gene, Accession, CAS #CAS: 552325-16-3
Catalog #16499-5
Price$401.00
Order / More InfoA-443654 from CAYMAN CHEMICAL COMPANY
Product Specific Referencesn/a
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640

Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com

http://www.caymanchem.com

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