A-770041 from CAYMAN CHEMICAL COMPANY

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Product NameA-770041
DescriptionAn orally bioavailable LCK kinase inhibitor (IC50 = 0.147 µM); selective for LCK over Src, Fyn, Fgr, HCK, and Tie2 (IC50s = 9.05, 44.1, 14.1, 1.22, and >50 µM, respectively); inhibits IL-2 production induced by an anti-CD3 antibody and PMA in isolated human whole blood (EC50 = 80 nM) and by concanavalin A in rats; prevents acute rejection and increases graft survival in a rat model of heterotopic heart transplantation at 10 mg/kg; inhibits the growth of CTV-1 cells (IC50 = 224 nM) and sensitizes U2OSMR and KHOSR2 multidrug resistant human osteosarcoma cells to paclitaxel and doxorubicin
Size1 mg
Concentrationn/a
Applicationsn/a
Other NamesA770041 IL2 Tie 2 antiCD3 12 myrisate 13acetate concanavalinA CTV1 osteo sarcoma
Gene, Accession, CAS #CAS: 869748-10-7
Catalog #32854-1
Price$57.00
Order / More InfoA-770041 from CAYMAN CHEMICAL COMPANY
Product Specific Referencesn/a
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640

Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com

http://www.caymanchem.com

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