Human Hexokinase Inhibitor Screening Kit from CREATIVE BIOMART

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Product NameHuman Hexokinase Inhibitor Screening Kit
DescriptionHuman Hexokinase II (HKII) Inhibitor Screening kit uses the HKIIs ability to convert glucose into glucose-6-phosphate. Glucose-6-phosphate is oxidized by glucose-6- phosphate dehydrogenase to form NADH, which reduces a probe that shows strong absorbance at 450 nm. In the presence of Bromopyruvic Acid, reactions are impeded, thus decreasing the rate and/or extent of generation of Hexokinase -dependent absorbance at OD 450 nm. Hexokinase Inhibitor Control is included to compare the efficacy of test inhibitors. This kit provides a sensitive, quick, and easy method for screening potential inhibitors of Hexokinase. The assay is high-throughput adaptable and can be performed in less than 30 min.
Size100 assays
Concentrationn/a
ApplicationsScreening/characterizing/studying potential inhibitors of human Hexokinase
Other Namesn/a
Gene, Accession, CAS #Hexokinases (HK, EC: 2.7.1.1) are found in many organisms including bacteria, plants and mammals and play an important role in glucose metabolism. The Hexokinase family phosphorylates glucose and generates glucose-6-phosphate for glycolysis. Four Hexokinase isoforms (HK-I, II, III and IV) are found in numerous species. HK-I, HK-II and HK-III have low affinity for glucose, one of their natural substrates, while HK-IV show high affinity for this monosaccharide. Recent studies have found increased hexokinase activity in various human metastatic tumors. Moreover, Hexokinase II (HKII) is the main isoform of the Hexokinases and is responsible for malignant phenotypes. HKII binds to the outer mitochondrial membrane via the Voltage-Dependent Anion Channel (VDAC), a Porin-like protein. HKII has become an attractive therapeutic target for its role in cancer metastasis.
Catalog #Kit-2111
Priceplease inquire
Order / More InfoHuman Hexokinase Inhibitor Screening Kit from CREATIVE BIOMART
Product Specific Referencesn/a
CREATIVE BIOMART
CREATIVE BIOMART
CREATIVE BIOMART
45-1 Ramsey Road
Shirley NY 11967
P: 1-631-619-7922
F: 1-631-938-8127

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