AAL-993 (CAS 269390-77-4) from LIFESPAN BIOSCIENCES INC.

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Product NameAAL-993 (CAS 269390-77-4)
DescriptionAAL-993 is a potent inhibitor of VEGF receptors, inhibiting VEGFR1, 2, and 3 with IC50 values of 130, 23, and 18 nM, respectively. It less potently inhibits c-Kit, colony stimulating factor 1 receptor, PGDF receptor Beta, and EGF receptor (IC50 s = 236, 380, 640, and 1,040 nM, respectively) and is without effect on a number of other tyrosine kinases. AAL-993 is orally bioavailable in vivo, blocks VEGF-induced angiogenesis, and prevents the growth of primary tumors and spontaneous peripheral metastases in mice. It also inhibits hypoxia-mediated increase in hypoxia-inducible factor-1 transcriptional activity in an ERK-dependent manner (IC50 = ~5 µM). Purity >95%
Size1 mg, 5 mg
Concentrationn/a
Applicationsn/a
Other Names2-[(4-pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]-benzamide. VEGFR Tyrosine Kinase Inhibitor VI, ZK 260253
Gene, Accession, CAS #CAS: 269390-77-4
Catalog #LS-H6367
Priceplease inquire
Order / More InfoAAL-993 (CAS 269390-77-4) from LIFESPAN BIOSCIENCES INC.
Product Specific Referencesn/a
LIFESPAN BIOSCIENCES INC.
LIFESPAN BIOSCIENCES INC.
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