Recombinant protein is a protein encoded by a recombinant DNA that has been cloned in a system that supports expression of the gene and translation of mRNA. The host cells used for recombinant protein production can be derived from bacteria, mammalian cell, insect and yeast. Recombinant proteins have been widely used in most hot research areas such as immune checkpoints, antibody drug targets, CAR-T cell therapy targets, Fc receptors, influenza viral proteins and cytokines.
MedChemExpress (MCE) offers a comprehensive catalog of recombinant proteins with excellent lot-to-lot consistency, superior activity and significantly low endotoxin levels for a variety of applications, including cell growth and differentiation, cell signaling, studies involving disease onset and progression and biopharmaceutical target discovery, protein structure and function analysis. MCE recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. Product quality is the key to our success and we take pride in offering only the highest-grade products. Product identity, quality, purity and biological activity are assured by our robust quality control and assurance policies, programs and procedures.Natural Products
A natural product is a chemical compound or substance produced by a living organism-that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. Natural products sometimes have therapeutic benefit as traditional medicines for treating diseases, yielding knowledge to derive active components as lead compounds for drug discovery. The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients.Inhibitory Antibodies
MCE Inhibitory Antibodies are monoclonal antibodies (mAbs) that have been extensively used in the hottest research areas, such as cancer, immunology and infection. These monoclonal antibodies (mAbs) bind monospecifically to certain cells or proteins, thus stimulating the immune system to attack the malignant tumor cells and preventing tumor growth by blocking specific cell receptors. They can inhibit PD-1, PD-L1, EGFR, VEGFR, TNF-alpha or other targets which are unusually active in diseases, such as non-Hodgkin lymphoma, Hemophilia A, renal cell carcinoma, Parkinson's disease and metastatic HER2-positive breast cancer. For example, by binding to VEGF, Bevacizumab prevents VEGF from interacting with its receptors, thereby inhibiting new vessel growth. Lambrolizumab targets the programmed cell death 1 (PD-1) receptor of lymphocytes. By preventing the binding of its ligands (PD-L1 and PD-L2), Lambrolizumab induces an antitumor immune response.Dye Reagents
A dye is a colored substance that has an affinity to the substrate to which it is being applied.
A new approach is presented for analysis of microplastics in environmental samples, based on selective fluorescent staining using Nile Red (NR), followed by density-based extraction and filtration. The dye adsorbs onto plastic surfaces and renders them fluorescent when irradiated with blue light. Fluorescence emission is detected using simple photography through an orange filter. Image-analysis allows fluorescent particles to be identified and counted. Magnified images can be recorded and tiled to cover the whole filter area, allowing particles down to a few micrometres to be detected. The solvatochromic nature of Nile Red also offers the possibility of plastic categorisation based on surface polarity characteristics of identified particles. This article details the development of this staining method and its initial cross-validation by comparison with infrared (IR) microscopy. Microplastics of different sizes could be detected and counted in marine sediment samples. The fluorescence staining identified the same particles as those found by scanning a filter area with IR-microscopy.
Cyanine dyes can be used to quantify the amount of dsDNA within a sample. The linearity of fluorescence, as function of DNA amount of six dyes, is obtained by measuring the fluorescence intensity at the optimal excitation and emission maxima.
Peptides are a group of biologically active substances that are involved in various cellular functions of organisms. Peptides are often used in functional analysis, antibody research, vaccine research and especially in the field of drug research and development. Peptides have a variety of biological functions, such as, anti-thrombosis, anti-hypertension, antibacteria, antivirus, anticancer and antioxidation, immunoregulation, and cholesterol-lowering effects.
MedChemExpress (MCE) offers a comprehensive collection of tag peptides, amino acid derivatives, blocking peptides, and bioactive peptides to clients in pharmaceutical and academic institutions all over the world. The bioactivity and safety of most bioactive peptides are confirmed by preclinical research and clinical trials. The peptides target on caspase, ACE, serine protease, integrins, JNK, and so on. And some peptides are the linkers for antibody-drug-conjugation. Tag peptides include common tags such as HA, FLAG, and c-Myc peptide.
Product quality is the key to our success and we take pride in offering only the highest-grade products. Product identity, quality, purity and activity are assured by our robust quality control and assurance polices, programs and procedures. We perform thorough analytical tests (HPLC and LC-MS), stability tests and activity assays on our peptides and the test results are available to clients. Comprehensive information such as purity, length, modification, sequence and recommended solvent will be provided.
Bioactive Screening Libraries
Our ready-to-use MedChemExpress (MCE) compound libraries consist of over 10,000 small molecules with validated biological and pharmacological activities. They are available for high-throughput screening (HTS) and high-content screening (HCS). Compound libraries are useful professional tools for drug discovery and new indication research.
• Safety and effectiveness have been confirmed by literature, patent reports and clinical research. Many products are FDA-approved.
• Focuses on hundreds of targets that are key components in the fields of GPCR, kinase, anti-cancer, epigenetics, stem cellbiology, etc.
• Up-to-date with the latest medical molecule developments and offers access to our exclusive Clinical Compound Library.
• Provides detailed biological and chemical information on every compound together with the LC/MS and NMR reports to ensure high quality.
We offer over 300 exclusive compounds worldwide and track the latest scientific innovations to give our customers access to the newest small molecules. We are dedicated to providing high-quality small molecules to our customers around the world.
MCE offers customized compound libraries based on your specific needs. You can select compounds, format (powder/liquid), size and plate map depending on your requirements.