SOX17 Antibody from BIOLEGEND

SOX17 is an important member of the SOX family of transcription factors, which are defined by possession of a homologous sequence called the HMG (high mobility group) box. SOX genes are primarily involved in developmental processes including germ layer formation, cell-type specification, and organogenesis. SOX17 activates endodermal target genes, and is required for the formation of endoderm and blood vessel endothelium. SOX17 also plays critical roles in the maintenance of fetal and neonatal hematopoietic stem cells. Additionally, SOX17 is a regulator of human primordial germ cell fate.

SOX17 also acts as a tumor suppressor through suppression of Wnt signaling, and a reduction of SOX17 expression is found in gastrointestinal and colon carcinomas. Additionally, mutations in SOX17 can induce stem-like characteristics in tumor cells by causing SOX17 to dimerize with OCT4 and induce pluripotency transcriptional programs.