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Product Name | Safinamide (mesylate) |
Description | An inhibitor of MAO-B (IC50 = ~0.1 µM); selective for MAO-B over MAO-A (IC50 = >10 µM); inhibits radioligand binding to sodium channel binding site 2, sigma-1, and sigma-2 receptors in rat brain membranes (IC50s = 8.2, 0.019, and 1.59 µM, respectively); inhibits high voltage-activated calcium currents and depolarization-induced tetrodotoxin-sensitive fast sodium currents in rat hippocampal neurons; inhibits veratrine-induced glutamate release in rat hippocampal slices (IC50 = 56 µM); inhibits maximal electroshock-induced tonic extension seizures in mice and rats (ED50s = 8 and 11.8 mg/kg, p.o.) as well as maximal seizures induced by bicuculline, picrotoxin, 3-mercaptopropionic acid, and strychnine in mice (ED50s = 26.9, 60.6, 21.5, and 104.1 mg/kg, p.o., respectively) |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | EMD 1195686|FCE 26743|NW-1015|PNU-151774E |
Gene, Accession, CAS # | CAS: 202825-46-5 |
Catalog # | 21546-10 |
Price | $115.00 |
Order / More Info | Safinamide (mesylate) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |