ASP3026 from CAYMAN CHEMICAL COMPANY
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| Product Name | ASP3026 |
| Description | An ALK inhibitor (IC50s = 3.5, 10, and 5.4 nM for the wild-type, ALKF1174L, and ALKR1275Q enzymes, respectively); selective for ALK over a panel of 86 kinases at 1,000 nM but also inhibits ROS1 and TNK2 (IC50s = 8.9 and 5.8 nM, respectively); inhibits the proliferation of Ba/F3 cells expressing NPM-ALK or ELM4-ALK fusion proteins (IC50s = 84 and 56 nM, respectively), as well as several crizotinib-resistant Ba/F3 cells expressing NPM-ALK or ELM4-ALK mutants; induces tumor regression in an NCI H2228 NSCLC mouse xenograft model at 10 and 30 mg/kg |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | alk atp-competitive asp-3026 ROS ACK WT ALK-F1174L R1275Q cRos nonreceptor TNK ELM NPMALK ELM4ALK H-2228 nonsmall |
| Gene, Accession, CAS # | CAS: 1097917-15-1 |
| Catalog # | 18491-1 |
| Price | $39.00 |
| Order / More Info | ASP3026 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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