MK-2461 from CAYMAN CHEMICAL COMPANY
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| Product Name | MK-2461 |
| Description | A c-MET inhibitor (IC50s = 0.4-2 nM for wild-type and mutant forms); selective for c-MET over a panel of 13 additional kinases (IC50s = 22-7,800 nM) but does inhibit Ron and FLT1 (IC50s = 7 and 10 nM, respectively); inhibits autophosphorylation of FGFR2 and PDGFRα in KATO III cells at 2 µM; reduces proliferation in a panel of cancer cell lines, including cells expressing constitutively active c-MET, FGFR2, or PDGFR (IC50s = ≤ 1 µM for all); reduces tumor growth in a GTL-16 gastric cancer mouse xenograft model (10-200 mg/kg) |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 1196681-15-8 MK2461 cMET FLT 1 FGFR 2 A 549 GTL16 |
| Gene, Accession, CAS # | CAS: 917879-39-1 |
| Catalog # | 32964-5 |
| Price | $319.00 |
| Order / More Info | MK-2461 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY