CU-CPT8m from CAYMAN CHEMICAL COMPANY
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| Product Name | CU-CPT8m |
| Description | An antagonist of TLR8 (Kd = 220 nM; IC50 = 67 nM in a reporter assay); is selective for TLR8 over a panel of all other human TLRs at 1 µM; inhibits increases in TNF-α and IL-8 mRNA expression induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells at 1 µM; inhibits R-848-induced increases in TNF-α protein levels in differentiated THP-1 monocytes and human PBMCs in a concentration-dependent manner; decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis. |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | CPT-8m CUCPT CUCPT8m TLR-8 TNFα IL8 R848 THP1 RA |
| Gene, Accession, CAS # | CAS: 125079-83-6 |
| Catalog # | 25349-1 |
| Price | $32.00 |
| Order / More Info | CU-CPT8m from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY