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Product Name | Epinastine (hydrochloride) |
Description | A histamine H1 receptor antagonist (apparent Kis = 1.41 and 1.62 nM using guinea pig cerebellar and lung membranes, respectively) and mast cell stabilizer; inhibits IgE-induced histamine, TNF-α, and IL-10 secretion in human CBMCs at 0.1 µg/ml; inhibits histamine-induced cutaneous vascular permeability in rats and bronchoconstriction in anesthetized guinea pigs (ID50s = 5 and 0.1 mg/kg, respectively); inhibits dye leakage into the conjunctiva in a rat model of passive anaphylaxis reaction-induced vascular hyperpermeability of the conjunctiva (ID50 = 9.7 mg/kg, p.o.); topical administration reduces lid edema, tearing, and redness, as well as the number of neutrophils and eosinophils in the lid fornix, in a mouse model of atopic conjunctivitis |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | WAL 801CL |
Gene, Accession, CAS # | CAS: 108929-04-0 |
Catalog # | 18136-10 |
Price | $33.00 |
Order / More Info | Epinastine (hydrochloride) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |