CB-103 from CAYMAN CHEMICAL COMPANY
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| Product Name | CB-103 |
| Description | An inhibitor of Notch signaling; binds to the BTD domain of RBPJ and inhibits the assembly of the RBPJ-NICD transcription complex; inhibits ligand-induced Notch signaling in HeLa cells expressing mouse Notch1, -2, -3, or -4 (IC50s = 1.5, 0.9, 1.1, and 2.9 µM, respectively); reduces expression of the Notch target genes HES1, MYC, and DTX1 in RPMI-8402 T-ALL cells; reduces tumor volume and increases survival in an HCC-1187 mouse xenograft model at 25 mg/kg |
| Size | 250 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | CB103 Notch-1 Notch2 Notch3 Notch4 HES DTX-1 RPMI8402 HCC1187 |
| Gene, Accession, CAS # | CAS: 218457-67-1 |
| Catalog # | 36293-250 |
| Price | $72.00 |
| Order / More Info | CB-103 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY