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Product Name | NCB-0846 |
Description | A TNIK inhibitor (IC50 = 21 nM); selective for TNIK over a panel of 46 kinases but does inhibit FLT3, JAK3, PDGFRα, TrkA, Cdk2/CycA2, and HGK by >80% at 100 nM; inhibits phosphorylation of TCF4 and autophosphorylation of TNIK in cell-based assays at 3 µM; inhibits the growth and colony formation of HCT116 cells in two-dimensional growth and soft-agar assays, respectively, as well as reduces tumor growth in an HCT116 mouse xenograft model; reduces tumor growth in PDX mouse models of colon cancer at 50 and 100 mg/kg |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | NPC0846 TRAF FLT JAK PDGFR Cdk CycA TCF HCT-116 auto-phosphorylation |
Gene, Accession, CAS # | CAS: 1792999-26-8 |
Catalog # | 33268-5 |
Price | $161.00 |
Order / More Info | NCB-0846 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |