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Product Name | CP 31,398 (hydrochloride) |
Description | A p53 stabilizing agent; increases active mutant p53 and p53 reporter gene expression without increasing total protein levels of p53 in H1299 lung cancer cells transfected with mutant p53; is cytotoxic to a panel of 12 human glioma cell lines expressing wild-type or mutant p53 (EC50s = 11.2-22.2 µM); decreases tumor growth in an A375.S2 melanoma mouse xenograft model and completely inhibits tumor growth in a DLD-1 colon cancer mouse xenograft model at 100 mg/kg; dietary administration suppresses lung adenocarcinoma formation in a mouse model of tobacco carcinogen-induced lung adenoma and adenocarcinoma formation at 50 and 100 ppm, |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 259199-65-0 CP-31398 CP31398 p-53 H-1299 A375S2 DLD1 WT |
Gene, Accession, CAS # | CAS: 1217195-61-3 |
Catalog # | 27455-1 |
Price | $34.00 |
Order / More Info | CP 31,398 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |