Ruxolitinib (phosphate) from CAYMAN CHEMICAL COMPANY
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| Product Name | Ruxolitinib (phosphate) |
| Description | A potent ATP mimetic that inhibits JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively; less selective for JAK3 (IC50 = 322 nM); blocks IL-6 signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM); reduces splenomegaly, decreases circulating levels of IL-6 and TNF-α, eliminates neoplastic cells, and prolongs survival in a mouse model of JAK2V617F+ MPN, |
| Size | 25 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | INC 424 (phosphate)|INCB 018424 (phosphate) |
| Gene, Accession, CAS # | CAS: 1092939-17-7 |
| Catalog # | 23215-25 |
| Price | $381.00 |
| Order / More Info | Ruxolitinib (phosphate) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY