BMS 986142 from CAYMAN CHEMICAL COMPANY
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| Product Name | BMS 986142 |
| Description | A BTK inhibitor (IC50 = 0.5 nM); greater than 20-fold selective for BTK over a panel of 384 kinases; inhibits BCR stimulation-induced calcium flux in Ramos B cells (IC50 = 9 nM), as well as BCR stimulation-induced proliferation of, and CD86 surface expression in, peripheral B cells (IC50s = 3 and 4 nM, respectively); inhibits by Fcγ receptor stimulation-induced TNF-α production in human PBMCs (IC50 = 3 nM); reduces the percentage of mice with severe proteinuria and increases survival in an NZB/W lupus-prone mouse model at 30 mg/kg per day; reduces hind paw tibiotarsal joint bone resrption and inflammation in a CAIA mouse model at 5 and 20 mg/kg |
| Size | 500 µg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | BMS986142 TNFα CD 86 TNFα |
| Gene, Accession, CAS # | CAS: 1643368-58-4 |
| Catalog # | 30927-500 |
| Price | $81.00 |
| Order / More Info | BMS 986142 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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