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Product Name | BMS 986142 |
Description | A BTK inhibitor (IC50 = 0.5 nM); greater than 20-fold selective for BTK over a panel of 384 kinases; inhibits BCR stimulation-induced calcium flux in Ramos B cells (IC50 = 9 nM), as well as BCR stimulation-induced proliferation of, and CD86 surface expression in, peripheral B cells (IC50s = 3 and 4 nM, respectively); inhibits by Fcγ receptor stimulation-induced TNF-α production in human PBMCs (IC50 = 3 nM); reduces the percentage of mice with severe proteinuria and increases survival in an NZB/W lupus-prone mouse model at 30 mg/kg per day; reduces hind paw tibiotarsal joint bone resrption and inflammation in a CAIA mouse model at 5 and 20 mg/kg |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | BMS986142 TNFα CD 86 TNFα |
Gene, Accession, CAS # | CAS: 1643368-58-4 |
Catalog # | 30927-1 |
Price | $152.00 |
Order / More Info | BMS 986142 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |