AB-680 from CAYMAN CHEMICAL COMPANY
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| Product Name | AB-680 |
| Description | An inhibitor of ecto-5'-nucleotidase (IC50 = 0.043 nM in CHO cells expressing the human enzyme); selective for ecto-5'-nucleotidase over NTPDase 1, NTPDase 2, NTPDase 3, and NTPDase 8 (IC50s = >10 µM for all); inhibits ecto-5'-nucleotidase activity in isolated human and mouse CD8+ T cells and isolated human PBMCs (IC50s = 0.008, 0.66, and 0.011 nM, respectively); reverses AMP-induced decreases in the proliferation of, and IFN-γ and granzyme B secretion by, isolated human CD4+ and CD8+ T cells at 200 nM; reduces tumor volume in a B16/F10 murine melanoma model alone and in combination with an anti-PD-1 antibody |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | Quemliclustat |
| Gene, Accession, CAS # | CAS: 2105904-82-1 |
| Catalog # | 32798-10 |
| Price | $422.00 |
| Order / More Info | AB-680 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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