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Product Name | ARV-771 |
Description | A PROTAC that drives BET family protein degradation; induces degradation of BRD2, BRD3, and BRD4 in 22Rv1 CRPC cells (DC50s = <5 nM for all); inhibits proliferation of and increases PARP cleavage in 22Rv1 cells in a concentration-dependent manner; reduces full-length androgen receptor protein levels and prevents R1881-induced increases in ERG in VCaP cells; induces tumor regression in a 22Rv1 mouse xenograft model at 30 mg/kg per day, s.c. |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | ARV771 BRD-2 BRD-3 BRD-4 E-3 R-1881 |
Gene, Accession, CAS # | CAS: 1949837-12-0 |
Catalog # | 21299-10 |
Price | $253.00 |
Order / More Info | ARV-771 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |