Macitentan from CAYMAN CHEMICAL COMPANY
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| Product Name | Macitentan |
| Description | A dual ETA/ETB receptor antagonist (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively); inhibits ET-1-induced intracellular Ca2+ increase in HPASMCs (IC50 = 0.9 nM) and contractions of isolated rat aortic rings (pA2 = 7.6 for ETA) and sarafotoxin S6c-induced contractions of isolated rat tracheal rings (pA2 = 5.9 for ETB); decreases mean arterial blood pressure in DOCA-salt hypertensive rats (ED50 = 1 mg/kg); prevents development of pulmonary hypertension and right ventricle hypertrophy in a rat model of hypertension; decreases the number of vascular and tubule-interstitial lesions and amount of glomerular damage in a rat model of diabetes |
| Size | 100 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | ACT-064992|Actelion-1 |
| Gene, Accession, CAS # | CAS: 441798-33-0 |
| Catalog # | 23304-100 |
| Price | $138.00 |
| Order / More Info | Macitentan from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY