LOXO-292 from CAYMAN CHEMICAL COMPANY
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| Product Name | LOXO-292 |
| Description | A RET kinase inhibitor; inhibits phosphorylation of a KIF5B-RET fusion protein expressed in HEK293 cells (IC50 = 4 nM); selectively inhibits proliferation of cancer cells containing RET mutations or gene fusions, including RETM918T-containing MZ-CRC-1 medullary thyroid and CCDC6-RET gene fusion-positive TPC-1 thyroid cancer cells, by 20 to 1,700-fold; improves survival in a CCDC6-RET gene fusion positive orthotopic PDX mouse model of brain cancer at 30 mg/kg |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | ARRY-192|Selpercatinib |
| Gene, Accession, CAS # | CAS: 2152628-33-4 |
| Catalog # | 33515-10 |
| Price | $87.00 |
| Order / More Info | LOXO-292 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY