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Product Name | ASP9521 |
Description | An inhibitor of 17β-HSD5/AKR1C3 (IC50 = 120 nM); selective for 17β-HSD5/AKR1C3 over AKR1C2 (IC50 = 20 µM); inhibits conversion of androstenedione into testosterone by 17β-HSD5/AKR1C3 (IC50s = 11 and 49 nM for human and cynomolgus monkey enzymes, respectively); inhibits androstenedione-dependent PSA production in and proliferation of LNCaP cells expressing 17β-HSD5/AKR1C3; inhibits androstenedione-induced intratumor testosterone production in a CWR22R prostate cancer mouse xenograft model at 3 and 10 mg/kg |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | ASP-9521 hydroxy-steroid 5-aldo 1-C3 1C-3 HSD-5 ARK-1C3 ARK1C-3 ARK-1C2 ARK1C-2 17-βHSD5 ASP-9521 intra-tumor CWR-22R CWR22-R |
Gene, Accession, CAS # | CAS: 1126084-37-4 |
Catalog # | 27308-10 |
Price | $92.00 |
Order / More Info | ASP9521 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |