Description | A fluoroquinolone antibiotic; active against clinical isolates of S. aureus, E. coli, K. pneumoniae, P. aeruginosa, and S. marcescens (MIC50s = 1, 0.12, 0.25, 0.5, and 1 mg/L, respectively); inhibits S. aureus DNA gyrase supercoiling activity and topoisomerase IV DNA decatenation (IC50s = 126 and 26.5 µg/ml, respectively); increases survival in mouse models of systemic S. aureus, E. coli, K. pneumoniae, P. aeruginosa, and S. marcescens infection (ED50s = 15.1, 2.2, 4.1, 120.3, and 7.6 mg/kg, respectively); reduces tumor growth in a 143B human osteosarcoma mouse xenograft model at 4 and 8 mg/kg |