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Product Name | CUDA |
Description | Epoxyeicosatrienoic acid (EpETrE; EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity.{12391} Soluble epoxide hydrolase (sEH) catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity. CUDA is an inhibitor of sEH exhibiting IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively.{14064} In COS-7 cells, 10 µM CUDA blocks conversion of 1 µM 14,15-EET to 14,15-DHET by 94%. CUDA activates peroxisome proliferator-activated receptor α (PPARα) 8-fold at a concentration of 10 µM but exhibits no affect on PPAR.delta. or PPARγ.{13447} |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | epoxides hydrolases hypertension dihydroxy eicosatrienoic acids DiHETrEs DHETs 11(12)-EETs 14(15)-EETs EpETrEs blood pressure soluble sEH inhibits inhibitors inhibition peroxisome proliferator-activated receptors PPARalpha PPAR.alpha. activates activation endocrinology |
Gene, Accession, CAS # | CAS: 479413-68-8 |
Catalog # | 10007923-5 |
Price | $47.00 |
Order / More Info | CUDA from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |