NS 8593 (hydrochloride) from CAYMAN CHEMICAL COMPANY
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| Product Name | NS 8593 (hydrochloride) |
| Description | An inhibitory gating modifier of SK channels (Kds = 0.42, 0.6, and 0.73 µM for SK1, SK2, and SK3, respectively, in the presence of calcium); decreases the calcium sensitivity of SK channels; selective for SK channels over IK and BK potassium channels at 10 µM; induces relaxation of potassium- or acetylcholine chloride-precontracted isolated tracheal rings from wild-type mice (IC50s = 8.9 and 39.8 µM, respectively) or from mice in an ovalbumin-induced model of allergic asthma (IC50s = 16.4 and 32.2 µM, respectively); inhibits aerosolized acetylcholine chloride-induced increases in respiratory system resistance in mice when administered as an aerosol at 500 µM; decreases the duration of burst-pacing-induced atrial fibrillation in normotensive and spontaneously hypertensive rats at 5 mg/kg |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 875755-39-8 NS8593 SK 1 2 3 |
| Gene, Accession, CAS # | CAS: 875755-24-1 |
| Catalog # | 29774-10 |
| Price | $172.00 |
| Order / More Info | NS 8593 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY