Vandetanib from CAYMAN CHEMICAL COMPANY
Search, find, compare suppliers for Vandetanib products.
| Edit | |
|---|---|
| Product Name | Vandetanib |
| Description | A multi-kinase inhibitor that inhibits VEGFR2, VEGFR3, VEGFR1, EGFR, PDGFRβ, Tie-2, and FGFR1 (IC50s = 40, 110, 1,600, 500, 1,100, 2,500, and 3,600 nM, respectively, in cell-free assays); also binds to 142 additional kinases in a panel of 442 kinases (Kds = 4.6-7,900 nM); induces apoptosis and cell cycle arrest at the G0/G1 phase in GEO colon and OVCAR-3 ovarian cancer cells at 1 and 2.5 µM; inhibits proliferation of HAK1-B, KYN-2, and Huh7 hepatocarcinoma cells and HUVECs (IC50s = 10, 8.1, 9.4, and 7.1 µM, respectively); increases survival and decreases tumor angiogenesis and VEGFR2 levels in a D54MG glioblastoma mouse xenograft model at 200 mg/kg; reduces tumor growth in a variety of mouse xenograft models at 25-100 mg/kg per day |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | CH 331|Zactima|ZD 6474 |
| Gene, Accession, CAS # | CAS: 443913-73-3 |
| Catalog # | 14706-5 |
| Price | $37.00 |
| Order / More Info | Vandetanib from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY