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Product Name | ARN810 |
Description | A SERD; binds to ERα and ERβ (IC50s = 6.1 and 8.8 nM, respectively); induces degradation of ERα in MCF-7 cells (EC50 = 0.7 nM); inhibits 17β-estradiol-induced ERα transcriptional activity in a reporter assay and reduces MCF-7 breast cancer cell viability (IC50 = 2 nM); inhibits 17β-estradiol-induced uterine weight gain in rats at 1 mg/kg; reduces tumor volume in tamoxifen-sensitive and -resistant MCF-7 mouse xenograft models |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | GDC-0810|RG-6046 |
Gene, Accession, CAS # | CAS: 1365888-06-7 |
Catalog # | 29595-10 |
Price | $223.00 |
Order / More Info | ARN810 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |