Edit |   |
---|---|
Product Name | Prenylamine |
Description | A calcium channel inhibitor; inhibits PMCA in isolated and purified pig cardiac sarcolemma; binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP PDE activity at 10-50 µM, an effect that is negatively associated with the concentration of calmodulin; shortens action potentials and decreases the inward calcium current in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine at 30 µM; decreases epinephrine, serotonin, and dopamine levels in rat brain at 50 mg/kg; decreases epinephrine levels in rat heart; protects anesthetized rats from coronary artery occlusion-induced arrhythmia at 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole at 5 mg/kg, |
Size | 50 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 47445-86-3 B-436 B436 Elecor SAN Sandoz 13-194 Segontin |
Gene, Accession, CAS # | CAS: 390-64-7 |
Catalog # | 29430-50 |
Price | $384 |
Order / More Info | Prenylamine from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |