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Product Name | NCI 126224 |
Description | A TLR4 antagonist; selectively inhibits NO production induced by LPS (IC50 = 0.31 µM) over the R-848, Pam3CSK4, and poly(I:C) in RAW 264.7 macrophages but also inhibits NO production induced by FSL-1 in the same cells at 0.6 µM; inhibits LPS-induced NF-κB activity in a reporter assay using BV-2 microglial cells and LPS-induced increases in IL-1β and TNF-α levels in RAW 264.7 macrophages (IC50s = 5.92, 0.42, and 1.54 µM, respectively) |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | NSC 126224 |
Gene, Accession, CAS # | CAS: 65974-52-9 |
Catalog # | 39520-1 |
Price | $36.00 |
Order / More Info | NCI 126224 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |