EAI045 from CAYMAN CHEMICAL COMPANY
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| Product Name | EAI045 |
| Description | A potent inhibitor of mutant EGFRs (IC50s = 0.076, 0.049, 0.002, and 1.6 µM for recombinant EGFRL858R, EGFRT790M, EGFRL858R/T790M, and wild-type EGFR, respectively); inhibits phosphorylation of EGFR in a concentration-dependent manner in H1975 cells; reduces proliferation of Ba/F3 cells expressing EGFRL858R/T790M and EGFRL858R/T790M/I941R from 0.01-10 µM; induces tumor regression and reduces EGFR signaling in mice bearing EGFRL858R/T790M, EGFRExon19del/T790M, and EGFRL858R/T790M/C797S tumors at 60 mg/kg/day with cetuximab, |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | EAI-045 EGFR-L858R T790M Exon19del I941R C797S H-1975 epidermal growth factor |
| Gene, Accession, CAS # | CAS: 1942114-09-1 |
| Catalog # | 19719-10 |
| Price | $275.00 |
| Order / More Info | EAI045 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY