NSC 319726 from CAYMAN CHEMICAL COMPANY
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| Product Name | NSC 319726 |
| Description | A p53 reactivator; selectively inhibits growth of human tumor cell lines containing mutant p53 over those containing wild-type p53 (IC50s = 0.1-1 and >10 µM, respectively); induces apoptosis in TOV112D (p53R175H), but not OVCAR3 (p53R248W) or SKOV3 (p53-/-), cells at a concentration of 1 µM; restores a wild-type conformation to human p53175 and mouse p53R172 mutant proteins and induces expression of p53 target genes in TOV112D cells; inhibits tumor growth in TOV112D, but not H460 (p53+/+), mouse xenograft model when administered at a dose of 1 mg/kg; has broad-spectrum antifungal activity (MIC50s = 0.1-2 µg/ml against a panel of pathogenic fungi) with >800-fold selectivity for fungi over human HUH-7 and HepG2 cells |
| Size | 25 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | NSC319726 p-53 p53-R175 R175H R248W R172TOV-112D OVCAR-3 anti-fungal HUH7 Hep-G2 H-460 175 R172 SKOV-3 |
| Gene, Accession, CAS # | CAS: 71555-25-4 |
| Catalog # | 23701-25 |
| Price | $385.00 |
| Order / More Info | NSC 319726 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
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